Biosafety laboratory
(I), biosafety laboratory definition
Adapt to the industry:Microbiology, biomedicine, biochemistry, animal experiments, genetic recombination Suggested level: Level 1 - Class 1
Biosafety laboratory, also known as biosafety containment for laboratories, is a protective barrier and management measure that avoids or controls the hazard of a pest that is being manipulated to meet biosafety requirements.Biology laboratorywithAnimal laboratory。
(two),Biosafety laboratory construction includes
Building layout and decoration, air conditioning, water supply and drainage, gas supply, electrical design, centralized control, security, construction technology, testing, training and many other aspects, especially the following aspects of the program must be fully considered:
1. Architectural layout and decoration plan
According to the safety requirements, the laboratory layout is reasonably divided into clean areas, semi-polluted areas and polluted areas. Special channels are set up for people and objects, and necessary buffer rooms are set up. Measures such as isolation and secondary isolation can effectively avoid crossover. Pollution, fundamentally prevent the spread of dangerous microorganisms; laboratory decoration uses reliable materials, reasonable construction measures to ensure that the clean laboratory-biosafety laboratory is always in a relatively sealed environment, preventing the escape of microorganisms, easy laboratory Cleaning and disinfection while avoiding external damage to the laboratory environment.
2, air conditioning system
The biosafety laboratory is a dangerous microorganism that poses a hazard to humans, animals, plants or the environment. It must maintain a relatively negative pressure environment in a clean laboratory-biosafety laboratory by using a reasonable air conditioning system. It is not destroyed to ensure that dangerous microorganisms in the laboratory cannot diffuse into the external environment.
3. Control system
The biosafety laboratory is a dangerous micro-organism. For the principle of strict pollution control, it requires real-time monitoring of the physics of equipment in each laboratory with the least maintenance personnel and optimized management and maintenance means. The environment ensures that the laboratory is always in a relatively negative pressure environment to prevent the leakage of dangerous microorganisms.
(two),Testing plan
Due to the special nature of the biosafety laboratory, in addition to strict design, construction and commissioning, in order to ensure its safety, it must be subjected to necessary engineering inspection and strict acceptance, and can be put into operation after meeting safety requirements and usage requirements. . In addition, some factors in the use process, such as non-professional management and use, high-efficiency filter replacement, etc., will have an impact on the safety of the laboratory. Therefore, regular testing in use is just as important.
(III) Technical parameters of biosafety laboratory
According to the biological risk degree of the objects handled by the laboratory, the microbiology laboratory is divided into four levels, of which the first level has the lowest requirement for biosafety isolation and the fourth level is the highest.
1. Classification of biosafety laboratories
2. Main technical indicators of the main laboratory
Description:
1. The noise in this table does not include the noise of biological safety cabinets and animal isolators. If the noise of the above equipment is included, the maximum should not exceed 68 dB(A).
2. The minimum negative pressure of the main laboratory of the third-class laboratory relative to the atmosphere shall not be less than -30Pa, and the minimum negative pressure of the main laboratory of the fourth-class laboratory relative to the atmosphere shall not be less than -50Pa.
3. For the main laboratory of the third-level laboratory for keeping animals, the minimum negative pressure relative to the atmosphere shall not be less than -50 Pa; the minimum negative pressure of the animal's fourth-level laboratory main laboratory relative to the atmosphere shall not be less than -60 Pa.
4. The parameters of the animal biosafety laboratory shall comply with the relevant requirements of GB14925-2001 "Experimental Animal Environment and Facilities".
